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Additionally, the BBB regulates substance transport into and out of the CNS, ensuring the chemical stability of the neuronal milieu and supporting normal neuronal metabolism, which is vital for the optimal functioning of the brain's 86 billion neurons

But here are some general guidelines: Severe deficiencies: Daily shots for 1 week, then weekly shots until levels normalize Moderate deficiencies: Weekly shots until the deficiency is corrected Maintenance dosing : Monthly shots to keep B12 levels optimal Its definitely possible to take B12 shots too often

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