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Dissociation between sensing and metabolism of glucose in sugar sensing neurones
A randomized, double-blind, placebo-controlled phase 2 study comparing the efficacy and safety of tirzepatide versus placebo in 196 patients with nonalcoholic steatohepatitis (SYNERGY-NASH) with or without diabetes is currently underway and is estimated to complete in 2024
[16] [18] The trial exclusion criteria for retatrutide reflect a similar precautionary approach and should not be interpreted as a confirmed risk in humans
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