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We found that homozygous knockin of the L973F-IR in mice results in alterations in signaling similar to those observed in vitro, i.e., decreased IRS-1mediated signaling and increased Shc-mediated signaling, and these lead to impaired insulin sensitivity and modest increases in either tibial or whole-animal growth
Ongoing clinical trials are currently investigating a single-dose regimen of Danuglipron for managing overweight and obesity (NCT04616339)
Mishra R, Raj R, Elshimy G, et al
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