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Its cyclic structure formed via a lactam bridge between lysine and aspartate residues confers substantially greater metabolic stability than native -MSH and the linear Melanotan 1 analogue, and produces a distinct, broad-spectrum receptor activity profile

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The sublingual mucosa offers several advantages over gastrointestinal delivery, and understanding both the promise and limitations of this route matters for researchers evaluating their options

doi:10.1016/j.mehy.2012.07.034, PMID: 22951418 Marshall HE, Stamler JS (2001) Inhibition of NF-kappa B by S -nitrosylation