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doi: 10.1159/000520910 8 CumminsR.HauserT

Human studies of glucagon receptor antagonism show a striking result: hepatic amino-acid clearance drops hyperaminoacidaemia develops skeletal muscle becomes the fallback source of amino acids This pattern mirrors the very changes we see under GLP-1RA therapy

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In one study, people with overweight or obesity who took semaglutide lost around 6% of their body weight after three months and nearly 11% after six months

3 Currently, three GLP-1s have been approved in the U.S