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For most people the honest answer is: often at first, then much less often once your stores are refilled

Backed by research

Longevity Markers Gene-network studies report modulation of stress-response and proteostasis pathways

But here are some general guidelines: Severe deficiencies: Daily shots for 1 week, then weekly shots until levels normalize Moderate deficiencies: Weekly shots until the deficiency is corrected Maintenance dosing : Monthly shots to keep B12 levels optimal Its definitely possible to take B12 shots too often

Proper peptide storage is critical for maintaining potency

This section provides everything needed to understand and implement this popular protocol