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2021;4:e2137575

Although both HL and LPL are the major lipases in human PHP, in contrast to LPL, HL activity is increased in the presence of high salt and does not require further activation by circulating serum-derived factors (58)

However, a recent study suggested that upregulated IL-11 drives APAP-induced hepatocyte death, and specific deleting IL-11RA1 in hepatocytes or IL-11 knockdown in mice protected against AILI [215]

HNMT is widely expressed in human tissues

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