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TNF-, tumor necrosis factor

Poor sleepor too little of itcan weaken the immune system and disrupt the gut-brain axis, a key communication line that helps maintain microbial balance

Research indicates that the senescence-associated secretory phenotype (SASP) suppresses local stem cell activity and promotes a pro-inflammatory microenvironment hostile to regeneration in aging tissues

Ongoing mechanistic studies and upcoming clinical trials will determine how these preclinical benefits translate to human disease

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