4.1.3 Inhibition of melanin synthesis by mediating MITF-related pathway It regulates the transcription of tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), activates various target genes related to melanin synthesis, and influences the reproduction, proliferation, and survival of melanogenic cells (Wellbrock and Marais, 2005
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Histopathological examination using H&E and AB-PAS staining revealed severe pathological changes in the colonic epithelium of DSS-treated mice
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