Research from the NCBI explains that those with severe deficiencies or trouble absorbing B12 might need regular doses to keep their levels steady
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This dramatically helps to quantify the improvement during treatment, in this situation, twice-weekly intramuscular injections of hydroxocobalamin, and it also identified which symptoms probably were unrelated to the deficiency
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10.1016/S0376-7388(99)00201-X 126
In these pharmacies of old, he said, pharmacists combined different drugs into a bespoke formulation for each individual patient