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Vitamin B12, Skin Changes, and Overall Appearance Skin deserves its own attention here because the changes from B12 deficiency are real but often attributed to other causes

Haematological symptoms are among the most recognised manifestations

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You might wonder how a pill works if you lack intrinsic factor: at very high oral doses, a small amount of B12 can be absorbed directly through the gut wall via passive diffusion, bypassing the need for intrinsic factor entirely [1] [3]