However, their usage should always be supervised by healthcare professionals due to potential side effects and interactions
2,3 In REDEFINE 1, adverse events were mainly gastrointestinal, (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)
Drug/Laboratory Test Interactions Persons taking most antibiotics, methotrexate, and pyrimethamine invalidate folic acid and vitamin B 12 diagnostic blood assays
Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8
Consistency matters particularly for eye area treatment, as this region shows aging early but also responds relatively quickly to intervention
doi: 10.1021/acs.jproteome.7b00035 62 Sanchez-AlvarezMZhangQFingerFWakelamMJOBakalC