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APP is also an iron oxidase that can oxidize Fe 2+ to Fe 3+ and transfer it out of cells (Duce et al., 2010)

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ICH Q7 discusses primary and secondary reference standards and notes that secondary reference standards should be compared against a primary reference standard before first use [15]

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(9) Studies have investigated whether 5-Amino-1MQ affects glucose metabolism, insulin signaling, or markers of insulin resistance

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