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GLP-1s appear to address these issues directly, improving how the body responds to insulin, dialing down bodywide inflammation, and helping blood vessels function more normally

[Abstract] J Exp Clin Cancer Res

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Additional mechanisms attributed to berberine in laboratory and animal studies include modulation of gut microbiota composition, inhibition of mitochondrial complex I, and effects on various signaling pathways including those involving insulin receptor substrate proteins

Diabetes Care 36 , 237244 (2013)

Another trial found that semaglutide users experienced better HbA1c control and reduced risk of cardiovascular disease