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In the SUSTAIN 1-7 series of clinical trials which investigated the effectiveness of once weekly semaglutide injections (Ozempic) for the treatment of diabetic and obese patients, semaglutide (Ozempic) consistently demonstrated significant reductions in HbA1c levels compared to placebo and other usual diabetes medications (metformin, sitagliptin, dulaglutide)

Example weekly step-up schedule Educational references usually start low and increase slowly to reduce GI side-effect intensity