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CA and INT-777 inhibit FOXO-1 transcriptional activity, downregulating PDK4 to enhance glucose metabolic flexibility (Eblimit et al., 2018)

This activation triggers several therapeutic effects: Insulin Secretion Enhancement GLP-1 receptor activation stimulates glucose-dependent insulin secretion from the pancreas

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Iran J Kidney Dis 2011;5(2):114-118

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