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[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas
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Similar content being viewed by others Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]
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