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HR 1.19, 95% CI 0.91.58), but not for the other DPP-4 inhibitors as in the TECOS study for sitagliptin (HR 1.00, 95% CI 0.831.20) or the CARMELINA study for linagliptin (HR 0.90, 95% CI 0.741.08) (57, 62, 64, 65, 68)

For example, care should be taken with histidine and N-acetylcysteine (NAC a stabilized form of the amino acid cysteine)

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Mechanism of certain drugs induced ototoxicity The following sections detail the ototoxicity of key drug classes, including anti-cancer agents, aminoglycoside antibiotics, cytostatic drugs, diuretics, and antimalarial medications (Fig