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& Zitvogel, L
doi: 10.4158/EP11009.OR
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It inhibits the activation of the NLRP3 inflammasome, regulates the TNF signaling pathway and Th17 cell differentiation, and reduces the expression of pro-inflammatory factors IL-1, IL-18 as well as pulmonary vascular remodeling-related factors MMP-2, MMP-9, Collagen one and Collagen 3, thereby alleviating PAH (Xin et al., 2020)
It occurs naturally in human plasma
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