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It adds a 13-amino-acid extension at the N-terminus and substitutes arginine for glutamic acid at position 3, which sharply reduces its binding to IGF binding proteins [1] [2]

[13] [14] This reduces the risk of hypoglycaemia compared with some other diabetes medications

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At the phylum level, Verrucomicrobia was increased, and at the genus level, Anaerotruncus , Akkermansia , Bifidobacterium , Coprobacillus , Intestimonas , and Clostridium_XVIII were increased, and Coprobacter was decreased in temozolomide treated mice when compared to the vehicle-treated mice

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