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Retatrutide (research code LY3437943) is a triple agonist that binds GIP, GLP-1, and glucagon simultaneously, setting it apart from the dual GIP/GLP-1 agonist tirzepatide and the GLP-1 mono-agonist semaglutide
Some estimates suggest that if just 10% of eligible employees started GLP-1 therapy, employer health costs could increase by 15% to 25%
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too
Continuing GLP-1 treatment may be beneficial for maintaining weight loss and improving glycemic control
People with one copy of an ACADM mutation may have mild symptoms, including problems with a ketogenic diet
Contact your GP or diabetes specialist nurse if you experience: Severe or worsening abdominal pain that is persistent, sharp, or different in character from typical bloating discomfort Persistent vomiting or inability to keep down food and fluids, which may indicate gastroparesis (severe delayed gastric emptying) or bowel obstruction Signs of dehydration including dark urine, dizziness, reduced urination, or extreme thirst Unintentional weight loss beyond your treatment goals, or inability to maintain adequate nutrition Blood in vomit or stools , which could indicate gastrointestinal bleeding Severe constipation lasting more than a few days despite usual remedies Symptoms that significantly impair your quality of life or prevent you from carrying out normal daily activities Sudden or persistent right upper abdominal pain (may radiate to the shoulder/back), fever, jaundice, pale stools, or dark urine, which could indicate gallbladder disease Seek urgent medical attention (A&E or call 999) if you develop: Sudden, severe abdominal pain with a rigid, board-like abdomen Persistent vomiting with inability to keep down any fluids Signs of pancreatitis: severe upper abdominal pain radiating to the back, often with nausea and vomiting Symptoms of bowel obstruction: absolute constipation (no passage of stool or gas), severe cramping, and progressive abdominal distension For urgent but non-life-threatening concerns, contact NHS 111 for advice
