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Psychiatry 14 , 46 (2024)

A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm

doi: 10.3389/fcdhc.2026.1772391 Received 20 December 2025 Revised 15 March 2026 Accepted 16 March 2026 Published 10 April 2026 Volume 7 - 2026 Edited by Arrigo Francesco Giuseppe Cicero, University of Bologna, Italy Reviewed by Alessando Mattina, IRRCS ISMETT/UPMC Italy, Italy Updates Copyright 2026 Jdrasek, Lisowska and Czupryniak

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A 2003 study of 15 people with atypical depression who took 600 mcg of chromium picolinate showed no significant improvement in depression symptoms or mixed results using two depression measurement tools

Given his results, while I might try just high dose serine first, adding NAC, nicotinamide riboside, glycine and carnitine also makes sense, as Mardinoglus research suggests