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Engages dopaminergic and serotonergic systems in rodent CNS injury models

First identified in 1977 from cerebral venous blood of rabbits during electrically induced sleep by Swiss researchers Schoenenberger and Monnier, DSIP has since been studied for its role in sleep architecture regulation, stress response modulation, and neuroendocrine activity

These include: Improved energy Weight loss Improved capacity to exercise Metabolic homeostasis The potential to boost longevity Are there side effects

While individuals with mild vitamin B 12 deficiency may not experience symptoms, blood homocysteine and/or MMA may be elevated (18)

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Tandon et al., 2022) the authors evaluated the quality of the clinical trial included in the qualitative synthesis, based on 5 items assessing the randomization process, blinding, and the dropout rate (i.e., the patients lost to follow-up)