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Methods Animals We developed a mouse model with a loxP flanked transcriptional blocking cassette inserted between exons 2 and 3 of the Gcg gene, as described previously [9]

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When food spends more time in the stomach, the intrinsic factor (a protein needed to absorb B12 in the terminal ileum) may have less opportunity to bind to dietary cobalamin

Side effect profiles for each drug also vary, though common effects can include gastrointestinal issues

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For context, about 60% of CagriSema participants hit the 20% weight-loss mark, and nearly 1 in 4 lost 30% or more