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Such alterations in OXPHOS levels may be connected to misfunctions in the oxidative phosphorylation process, in accordance with a study reporting that a pharmacologically induced 5-HTT inhibition damaged the activity of the supercomplexes ( In line with the OXPHOS dysregulation, we found that 5-HTT / animals showed a significant decrease in antioxidant enzyme Cat mRNA levels in the amygdala and prefrontal cortex and increased expression of Gpx1 in the amygdala, possibly indicating an alteration of the activity of these enzymes to cope with the possible increase of ROS, due to the OXPHOS alteration

Furthermore, activated Ras is also implicated in inducing activation of GP2 and increasing expression of GGT transcriptional products and protein in colon cancer cells treated with naphthoquinone during acute oxidative stress (Fig

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