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However, panellists also agreed that, in the absence of evidence and clear, consistent guidance, there is a need for an expert-endorsed treatment algorithm, to support clinical decision-making for adults with CKD and T2D

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Since kidney function is reduced during AKI, activation of the urea cycle and subsequent urea generation together lead to a substantial rise in BUN 14,35

Similarly, to measure ascorbate (ASC), we adopted the method used by Foyer et al

Although retatrutide's mechanism of action is designed to minimise the risk of hypoglycaemia when used as monotherapy, certain groups of patients may face a higher risk, particularly as the drug is being studied in populations already managing type 2 diabetes or obesity with existing medications

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