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Diabetes, Obesity and Metabolism, 2024, 26(6): 2001-2016

These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (71)

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Researchers studying pure angiogenesis, ECM remodeling, or cytoprotection without inflammatory confounders should choose GLOW

The Matrifix patch is an example of a patch that supports the ECM