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During obesity-induced adipose tissue remodeling, abnormal secretion of proinflammatory factors and adipokines promotes tumor cell proliferation, invasion, and metastasis, accelerating tumor progression

Because immune benefits are systemic rather than visible, results are often felt before they are measured

The other two peptides degrade slowly through aspartate isomerization and glutamine deamidation

In clinical trials where a GLP-1 RA was added to background basal insulin, a general 20% basal insulin reduction in all patients or a 20% reduction in patients with an A1C 8.0%, the GLP-1 RA can be reasonably initiated without a reduction in the basal insulin dose for many patients