As a board-certified bariatric and weight loss surgeon, Ive worked with thousands of patients struggling with obesity, metabolic disease, and long-term weight management
Therefore, the trophic effects of GLP-1R signaling appear to target the distal gut (small intestinal length, large bowel length and weight) (Koehler et al., 2015)
Zepbound and Wegovy are FDA-approved for weight loss, Ozempic and Mounjaro are approved for type 2 diabetes, has been used off-label for weight loss, if appropriate
Retatrutide side effects may not stop immediately after the last dose
Regulatory Toxicology and Pharmacology (2020) 12
For manufacturers, the potential for this wider therapeutic use is worth billions of dollars