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The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

Preclinical research commonly uses 250500 mcg per day for musculoskeletal applications [3] [4]

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[13] [15] The frequency and severity of side effects are influenced by the dose, route of administration, and individual patient factors

Avoid freeze-thaw cycles to preserve both peptide components