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Pediatric obesity: Eventual development in adolescents with obesity is likely, following the pathway established by semaglutide (approved for adolescent obesity) and tirzepatide
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All study participants were older men with an average of 66 7.07 years of age (Table 1)
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Therefore, this study focuses on designing semaglutide analogues with site-specific missense mutations, and aims to strengthen GLP-1R activation through enhanced GLP-1R ECD binding affinity [26], contributing to the development of next-generation GLP-1R agonists with improved efficacy and specificity
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