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GIP and GLP-1 play a role in stimulating insulin production, regulating appetite, and regulating blood sugar levels

Duan H, Jing L, Xiang J, Ju C, Wu Z, Liu J, Ma X, Chen X, Liu Z, Feng J, Yan X (2022) CD146 associates with Gp130 to control a macrophage pro-inflammatory program that regulates the metabolic response to obesity

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Ozempic was (and still is) not FDA-approved for weight loss in patients without diabetes

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Instead, it operates through a cluster of regenerative and cytoprotective pathways