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2022 Mar 7;20(1):111
When you're dehydrated: Plasma osmolality rises (more concentrated blood) The hypothalamus signals the choroid plexus to reduce CSF production to conserve water Total CSF volume drops from the normal 125-150 mL to as low as 100-110 mL The brain sits lower in the skull with less hydraulic support Position changes create larger pressure differentials A 2020 study in Fluids and Barriers of the CNS (Bothwell et al.) measured CSF production in mildly dehydrated subjects (2% body water loss, equivalent to missing 2-3 glasses of water per day) and found a 17% reduction in CSF turnover rate within 48 hours
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89% of patients demonstrated clinical benefit with various GLP-1 receptor agonists across a broad range of MCAS-associated problems
Why Baseline Labs Matter Before GLP-1 Therapy GLP-1 receptor agonists are among the most effective metabolic medications available today
Substance P is an important neuropeptide and acts as both a vasodilator and sympathetic activator
