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Similar content being viewed by others Introduction Diminished growth hormone (GH) and insulin/insulin-like growth factor-1 (IGF-1) signaling extends lifespan in many laboratory models, including mutations to daf2 in worms 1 , Sch9 in yeast 2 , and Chico in drosophila 3

Another relevant point that has been highlighted in the present case report is whether melanotic macules with melanocytic hyperplasia/dysplasia can be considered as premalignant lesions/precursor lesions/transitional lesions for the development of future melanomas

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