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Exenatide is particularly sensitive to several chemical and physical degradation mechanisms, including: Oxidation Deamidation Truncation Aggregation These degradation pathways may occur during: Peptide synthesis Manufacturing processes Storage conditions Formulation handling Because even small molecular modifications can affect biological activity and stability, highly sensitive analytical workflows are required for accurate characterization and reliable biosimilar bioanalysis

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No dose adjustments are required for renal or hepatic impairment per FDA labeling, as tirzepatide is primarily metabolized through proteolytic pathways