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Short-term GHK-Cu use (weeks to few months) typically shows benefits gradually declining toward baseline over 2-4 months post-discontinuation as newly synthesized collagen undergoes normal degradation without replacement at treatment-stimulated rates

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JAMA Neurol (2013) 70(9):11779.10.1001/jamaneurol.2013.3197 46 AvulaSParikhSDemarestSKurzJGropmanA

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