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By making LPS-induced depression model mice, drug treatment, behavioral tests, and detection of hippocampal tissue samples, it was found that SGD can regulate the levels of IL-10, TNF-, BDNF, SMAD3, FGFR1, and FGFR2 to improve the depressive state, providing a theoretical basis for exploring the efficacy of SGD in the treatment of depression ( 4.4.2 Oxygen deficiency protection HIF1A (Hypoxia-Inducible Factor 1-Alpha) is a core transcription factor for cells to sense and respond to a hypoxic environment, playing a key role in pathophysiological processes such as tumor progression, inflammation, and metabolic reprogramming

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But that barrier limits how much topically applied GHK-Cu actually reaches the follicles