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As the half-life of retatrutide is 6 days, once weekly administration was sufficient with as expected gastrointestinal disturbance being the most common side effect and occurring in 63% of those on retatrutide, 60% on dulaglutide, and 54% of the placebo cohort [63]

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Add MOTS-c at Week 5 once tolerance is set

But, long-term studies have also raised concerns about side effects like pancreatitis and gallbladder disease

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Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling