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GLP-1 binds to receptors (GLP-1R) in the hindbrain, hypothalamus, lateral septum and cortex, engaging circuits that inhibit food intake (extensively reviewed in previous work 8 )
GLP-1R-immunoreactivity was only observed in association with some thin astrocyte processes, but it could not be determined unequivocally whether GLP-1R-immunoreactivity was present on their surface or on a neighboring structure
Conclusion Tirzepatide marks a notable advancement in the management of type 2 diabetes and obesity, demonstrating its dual action on GLP-1 and GIP receptors to enhance insulin secretion and facilitate weight loss
10.1517/17460441.2013.741580 76 PattersonJ
Lancet, 303, 963965
Its primary actions include: Inhibiting the reuptake of dopamine and noradrenaline in the central nervous system Minimal effect on serotonin pathways, distinguishing it from most other antidepressants Potential appetite suppression as a secondary effect, though this is not its primary indication Reducing nicotine cravings through dopaminergic pathways Bupropion is metabolised primarily in the liver by the CYP2B6 enzyme system, producing active metabolites
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