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For patients with type 2 diabetes and significant beta-cell dysfunction, intensification with insulin therapy may be necessary

The drug semaglutide can be used for weight loss, along with diet and exercise, when treating type 2 diabetes

Extracted variables included author, year, country, study design, sample size, patient characteristics, type of intervention, dosage and duration, targeted complication, outcome measures (clinical, biochemical, or patient-reported), and key findings

Byetta and Bydureon (exenatide) : among the earliest GLP-1 medications approved in the United States, available in twice-daily and once-weekly injectable forms