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Topical serums benefit from refrigeration after opening but can survive at room temperature for shorter periods

Unexpected Symptoms New or persistent symptoms should be discussed with the provider rather than assumed to be a normal part of treatment

To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig

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UK patients should understand that: Available evidence is largely from Phase 2 studies with relatively short follow-up periods Long-term cardiovascular outcome data are not yet available for either agent Phase 3 trials are ongoing, and results will inform future regulatory submissions to the MHRA UK patients interested in accessing these treatments through clinical trials may wish to consult the NIHR 'Be Part of Research' portal (bepartofresearch.nihr.ac.uk) or ClinicalTrials.gov for current recruitment opportunities