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For patients who travel frequently or have unpredictable schedules, oral or topical options may be more practical during certain periods

While omeprazole is useful for GERD and PUD, its use is not without the increased risk of other complications, such as an increased risk for aspiration pneumonia in certain patients, clinically relevant drug-drug interactions, and complications related to vitamin B12 deficiency, such as macrocytic anemia, hyperhomocysteinemia, and/or neuropathies.1-7 The focus of this article is related to the mechanism by which omeprazole could cause a deficiency in vitamin B12

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This includes things like mild symptoms such as skin rash or allergic reactions

Its mechanism of action is multifaceted centred on copper transport, collagen synthesis modulation, and broad-spectrum gene expression regulation

DSIP directly addresses this by decreasing basal corticotropin levels and blocking cortisol release