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Analytical challenges in GLP-1 drug development Sensitivity: GLP-1 and its analogs are present at low concentrations in biological matrices and are rapidly cleared, requiring highly sensitive detection methods
Together, they create a potent synergy, maximizing benefits while reducing side effects
Plasma concentrations return to baseline within 12 hours after intravenous administration of 0.5 g [5][12]
doi: 10.1016/j.immuni.2015.05.018 69 DeRubertisBGStilesBMBhargavaAGusaniNJHezelMDAngelicaMet al
These effects mirror what has been seen with GLP-1 therapies but are often less intense when appropriate titration protocols are followed
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