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Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26
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It's an ambiguity acknowledged by the review's authors, who state that more research is needed to clarify optimal amounts and to identify "sub-groups of individuals most likely to respond to particular nutrients or foods." Speaking with a doctor is your best first-line action to determine whether you could benefit from swapping dietary glutathione for a supplement, or vice versa
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