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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist drug, FDA-approved for type 2 diabetes mellitus (Ozempic and Rybelsus) and chronic weight management (Wegovy)

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DOX (Doxorubicin), CP (Cyclophosphamide), PARP-1 (Poly (ADP-Ribose) Polymerase 1), Bcl-2 (B-Cell Lymphoma 2), AC (Anticancer Chemotherapy), IL-3 (Interleukin-3), NF-B (Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells), COX-2 (Cyclooxygenase-2), IL-3 (Interleukin-3), CYP (Cyclophosphamide), 5-FU (5-Fluorouracil), MTX (Methotrexate), SOD (Superoxide Dismutase), CAT (Catalase), GPx (Glutathione Peroxidase), GST (Glutathione S-Transferase), MDA (Malondialdehyde), ROS (Reactive Oxygen Species)

10.1016/j.jacc.2010.07.053 234 MeyerC.StumvollM.DostouJ.WelleS.HaymondM.GerichJ

Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd