Mitochondrial dysfunction is not presented here as a universal explanation for autism
FOXO4-DRI selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 interaction that keeps these damaged zombie cells alive, without harming healthy cells
The 13-amino-acid N-terminal extension adds steric interference
These findings support the potential for 5 amino 1mq as a safe, effective metabolic intervention
The distance between the two IPT2 domains of c-METs in this structure is ~20 , hinting that the two membrane-proximal IPT4 domains of c-METs are likely to be positioned in proximity in this specific dimeric conformation that allows the intracellular KDs to undergo trans -autophosphorylation
The great advantage of this method is that also toxic bidentate or tridentate iron chelators can be modified by conjugation with NPs into less toxic hexadentate chelators that hold high kinetic stability, without affecting their iron binding capacity (Hider, 1994
