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6 In a randomized, controlled, crossover study in healthy subjects, consuming 180 mg of curcumin before a carbohydrate-rich meal significantly reduced the incremental area under the curve for plasma glucose over 120 minutes by approximately 36 percent compared with control, without major adverse events

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Spironolactone and caffeine Caffeine is a stimulant that may have a diuretic effect, similar to spironolactone