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French physiologist Jean La Barre first used the term incretine in 1932 to describe a substance which lowered glucose levels by augmenting insulin release and actions.4 5 We now know that GLP-1 and glucose-dependent insulinotropic peptide (GIP) are the two main incretin hormones

8 FDA-approved treatments exist and are fully available

Appetite reduction usually begins within the first few days Mild GI side effects are most common during this period Weight loss of 2-5 pounds is typical Energy levels may fluctuate Weeks 5-12: Building Momentum As your dose is titrated upward, effects become more pronounced

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doi: 10.1016/j.nutres.2010.08.008 107 RaoCVDesaiDSimiBKulkarniNAminSReddyBS

By slowing gastric emptying, stabilizing blood sugar, and sending powerful Im full signals to the brain, semaglutide makes it easier to reduce calorie intake without whiteknuckle cravings