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Phase 3 data on retatrutide (triple GLP-1/GIP/glucagon agonist) showing nearly 29% weight loss, the pending approval of CagriSema (GLP-1/amylin combination), and the arrival of oral non-peptide GLP-1 agonists like orforglipron all suggest we are at the start of a metabolic therapeutics renaissance

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Patients with respiratory chain defects or mitochondrial disorders and secondary carnitine deficiency may present with abnormal fatigability and lactic acidosis associated with exertion

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