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Baseline metformin, sulfonylurea, and insulin use was similar for participants in EMPA-REG, CANVAS Program, LEADER, and SUSTAIN-6 (Online Figure 2A)

It originated as part of Lilly's program to extend the dual-agonist concept proven by tirzepatide into a triple-agonist class, and it is the first such molecule to advance into Phase 3 in any indication [1][3][4]

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